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Moreover, fourteen articles had an unclear risk of selection bias for random sequence generation and allocation concealment [11, 15, 19, 24, 26, 27, 30, 32, 3942, 46, 47], thirteen articles presented unclear risk of bias for blinding [15, 19, 24, 28, 31, 32, 3638, 41, 44, 46, 47], while three articles showed an unclear risk for attrition bias, reporting bias and other sources of bias [23, 27, 31]

(3), which did not estimate sensitivity and, therefore, the number of true anaphylaxis cases that might have been missed is unknown

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Retatrutides GIP receptor binding constant is 16 lower (tighter) than tirzepatides, which is why the GIP curve fills faster on retatrutide than the equivalent dose of tirzepatide would