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N Engl J Med (2017) 377(1):1327
Others may need medical nutrition therapy, obesity medicines, endoscopic options or bariatric surgery depending on their BMI, eating behaviour, diabetes status, sleep issues and long-term weight history
Patients were initially eligible for surgery if they had a BMI of 40 kg/m 2 or higher, or a BMI between 35 and 40 kg/m 2 with significant comorbidities according to French guidelines [27]
In contrast, a peripheral injection of EX4 in rats reduced both basal locomotor activity and amphetamine-induced hyperactivity, which may be indicative of a reduced dopamine signal
