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Why Doctors Choose One Medication Over Combining Both Experienced weight loss physicians prioritize a stepwise approach rather than combination therapy

Without insurance, you can purchase semaglutide out-of-pocket at the retail price
Metformin is more flexible: it comes as immediate-release tablets you take 1 to 2 times a day, or extended-release tablets you take once daily

Patients aiming for targeted fat loss should combine semaglutide with lifestyle modifications: dietary adjustments and physical activity