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In addition, the leptin-receptor-expressing (LepR) neural activity in the dorsomedial hypothalamus (DMH), which sends GABAergic inhibitory inputs to ARC AgRP neurons, is also known to be rapidly increased by sensory detection, the taste of food, or food cues [48,53,54]

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Individuals with a personal or familial history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should avoid this medication because of the potential risk of thyroid neoplasms observed in preclinical studies