semaglutide heart failure reduced ejection fraction Efficacy of by Sex in Obesity-Related With Preserved Fraction: STEP-HFpEF Trials In patients with cardiometabolic #HFpEF,

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This alignment from mechanistic insights to clinical application supports the biological validity of our findings

-cell apoptosis is mediated by a series of cascade mechanisms of the cysteine protease family, and current studies on hyperglycemia-induced -cell apoptosis have focused on the balance between the pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and the anti-apoptotic Bcl family (Bcl-2 and Bcl-xl) (Tomita, 2016), and apoptosis occurs only when the concentration of the pro-apoptotic protein Bcl-2 on the mitochondrial membrane of the intrinsic pathway exceeds the concentration of the anti-apoptotic protein

The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE/ and LDLr/ Mice by a Mechanism That Includes Inflammatory Pathways. JACC: Basic to Translational Science , vol