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Arterburn DE, Telem DA, Kushner RF, Courcoulas AP

Initially developed for glycemic control in T2DM, GLP-1 RAs act as incretin mimetics by stimulating glucose-dependent insulin secretion and inhibiting glucagon release ( 2 Global epidemiology and SLD progression to HCC HCC is a significant global health threat, ranking as the fourth most common cancer and the second leading cause of cancer-related mortality worldwide ( 3 Spectrum of SLD and mechanisms of progression to HCC HCC predominantly arises in the setting of chronic liver injury, but the specific insults (metabolic excess, alcohol, or viral infection) converge upon a common pathogenic pathway: dysregulated hepatic metabolism

4,5 Psychotropics may further increase this cardiometabolic risk

Additionally, the magnitude of clinical effects differs substantially