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b Novo Nordiskdefined hypoglycemia: a severe hypoglycemia event or an event where laboratory or self-measured glucose calibrated to plasma was 15 years Episode of hypoglycemia e within previous 12 weeks Treatment arm 1 Treatment arm 2 Full treatment period: 64 weeks A1C NONINFERIORITY IN BOTH TREATMENT PERIODS WAS A PREREQUISITE Primary endpoint (noninferiority) was achieved, then tested for superiority: Tresiba demonstrated superiority vs insulin glargine U-100 in terms of rates of severe or BG-confirmed symptomatic hypoglycemic episodes during the maintenance period

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Despite having minimal effects on body weight, treatment with -MSTN/-ActA alone also showed beneficial shifts in the lean/fat body composition in obese mice as previously shown in non-obese mice, NHPs, and humans (Fig