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However, as noted above, intervention trials of oral SCFA butyrate supplementation have shown no effect on glycaemic control or other markers of diabetes regulation in either type 1 or type 2 diabetes [116, 122, 123, 206], probably because the site of delivery does not mimic endogenous production

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We report the 12-month primary safety and tolerability outcomes of a multicenter, open-label, dose-escalation, phase 1 trial evaluating BBM-P002, a new adeno-associated virus vectorAAVT42codelivering constitutively active TH and AADC

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