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Dual and multi-agonists, including agents targeting GLP-1/GIP and GLP-1/GCGR pathways, are emerging as next-generation therapies with enhanced metabolic benefits

The rats were 8 weeks old at the initiation of the studies with a body weight of 250325 g

Sitagliptin (25 M), NVP-DPP728 (270 M), or liraglutide (1000 ng/mL) treatment significantly reduced oxidized-low-density lipoprotein-induced or PKC activator-induced protein expression of nucleotide-binding domain-like receptor with a pyrin domain 3 (NLRP3), toll-like receptor 4 (TLR4), and IL-1 in a human monocytic cell line, THP-1, by decreasing phosphorylated-protein kinase C (PKC) [64]

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