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Notably, the majority of mechanistic data supporting this concentration-dependent model derives from preclinical studies using mouse pancreatic -cells and clonal cell lines, with limited validation in human islet studies, necessitating further clinical investigation to confirm these concentration thresholds in human diabetes treatment [23,24,25,26]
The LEAN trial included patients with and without T2DM, and showed a greater beneficial effect for the liraglutide treatment of NASH resolution, without worsening of fibrosis in patients with T2DM (RR = 4.7
2020;105(4):dgz069
