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The SELECT trial showed significant reduction in heart attacks, strokes, and cardiovascular death
Retatrutide was associated with a greater increase in resting heart rate than tirzepatide in clinical trials

Our bodies are remarkably good at defending body weight
Despite these differences, and despite the caveats that patients are receiving both presurgical and postsurgical dietary counseling, early reductions in food intake drive early surgery-induced weight loss in both humans (98) and rodents (39)