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It is typically worst during the first few weeks and during dose escalations

If you have kidney disease or other health conditions, personalised dietary advice from a dietitian may be beneficial

However, weight loss may eventually lower your levothyroxine requirement, so TSH monitoring every 68 weeks during the first three months is important

Regular Social Drinkers (1-2 Times Weekly) If you drink weekly at dinner, social gatherings, or as part of regular routines: Reduce your typical consumption by 40-50%: If you usually had 2-3 drinks, limit to 1-2 Establish a maximum of 2 drinks per session: Regardless of previous tolerance Take 2-3 days between drinking occasions: Give your liver adequate recovery time Monitor for persistent GI issues: If nausea or reflux becomes chronic, reassess alcohol frequency Get liver function tests every 6 months: Track ALT, AST, GGT to ensure no cumulative effects Consider your weight loss goals: Regular alcohol consumption can slow retatrutides effectiveness At this frequency, both acute intoxication risks and potential cumulative liver effects become relevant considerations