ozempic weight regain after stopping semaglutide Obesity Medications: NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD, explains a recent meta-analysis that showed projected return to baseline weight within 2 years Gaining weight back after Ozempic

Semaglutide has 94% structural similarity with the GLP-1 produced naturally by the human body

Market Drivers: Rising prevalence of diabetes and obesity is a key driver of revenue growth in the GLP-1 Receptor Agonist market

Also, insurance companies typically do not cover off-label drugs such as Ozempic and Rybelsus prescribed for weight loss

Based on CVS Caremark's own prior authorization data (obtained through Freedom of Information requests by the Obesity Action Coalition, 2025): 100% of patients request coverage 34% receive approval on first PA submission 24% receive approval after appeal 58% total approval rate Of approved patients, 41% abandon treatment after the first fill due to out-of-pocket cost (coinsurance averaging $380/month) Effective coverage rate: 34% of patients who request Wegovy through CVS Caremark receive it AND continue past the second fill