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The metabolic protection of maintained muscle mass becomes the primary defense against the caloric surplus that drives weight regain
SURPASS-CVOT compared once-weekly tirzepatide with dulaglutide in adults with type 2 diabetes and high cardiovascular risk, showing a 9% relative risk reduction in MACE (HR 0.92, 95% CI 0.83 to 1.01)
The color was a quality-control hack as much as a clinical feature
For example, a 72-week phase II trial involving 320 patients with MASH, reported MASH resolution rates of up to 59% at the highest dose of 0.4 mg daily as compared to 17% in the placebo group
