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This enhanced insulin response helps with weight loss but means that a given amount of sugar produces a stronger metabolic reaction than before starting the medication

Hypothetical pathophysiological mechanism of ischemic colitis associated with tirzepatide Schematic diagram illustrating the proposed pathophysiological cascade linking tirzepatide therapy to ischemic colitis

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Gastrointestinal adverse effects are among the most commonly reported side effects of Mounjaro, occurring in a significant proportion of patients, particularly during dose initiation and escalation