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Early constraints centered on synthesis capacity, but as fragment-based approaches improve throughput, purification and the analytics required to support purification are becoming more important limitations

In people who struggle with obesity or metabolic dysfunction, this signaling system can become sluggish

The therapy was also generally well tolerated, with mostly mild injection-site reactions and no increased risk of serious infections, thrombosis, or cardiovascular events

Red flags that require medical evaluation A sustained resting heart rate above 100 beats per minute (tachycardia) at rest is never normal and should prompt medical evaluation regardless of the cause
