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GLP-1 therapies have shown promise in reducing liver fat content, mitigating the progression of NAFLD

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The clinical evidence establishes unprecedented therapeutic efficacy across established indications, with newer multi-receptor agonists achieving HbA1c reductions exceeding 2.0% in diabetes, weight loss approaching 24% in obesity that rivals bariatric surgery outcomes, and cardiovascular protection demonstrating consistent 1420% MACE reduction with emerging benefits in heart failure with preserved ejection fraction

Besides DM, cardiovascular diseases, and hypertension are important comorbidities that are potentially involved in determining the severity of the infection, disease outcomes, and prognosis [30]