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Description
Based on the annualized event rates in the semaglutide and placebo groups, the SOUL trial was calculated to accumulate 1225 events at the end of 3.78 years, resulting in premature termination (Fig

We monitor for plateaus and address them early

Never double up on doses, as this increases side effect risk without improving efficacy

For instance, VSG causes anemia, ulcers, hernias, vomiting, dumping syndrome (74, 75), depression (76, 77), and bone loss, evidenced by reductions in BMD at femoral neck, total hip, and lumbar spine (78)