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Many patients report injection-site soreness or needle discomfort when starting semaglutide therapy, though studies show that pain sensitivity decreases significantly after the first 23 injections

doi: 10.1210/er.2018-00168 [DOI] [PubMed] [Google Scholar] 173.Jonklaas J, Bianco AC, Bauer AJ, et al

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Acutely increasing LV preload in a baseline abnormal LV may lead to distention, lowered cardiac output, and pulmonary edema