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Fatigue is listed as a common adverse reaction (occurring in 5% of patients) in the FDA prescribing information for both Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide), and occurred more frequently than with placebo in clinical trials

Some studies have demonstrated the ability of gut-derived GLP-1 to cross through the blood-brain barrier and thoroughly perfuse the brain parenchyma, but whether its effects are similar to that of PPG-derived GLP-1 remains to be established [50, 53]

Glucagon-Like Peptide-1 Receptor Agonists.[Updated 2023 Jan 13]

It achieves this by inhibiting neutrophilia triggered by aeroallergens and decreasing the release of IL-5 and IL-13