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No rough estimates

In these drug-naive individuals with prediabetes, the gut microbiota exhibits many early alterations such as a loss of butyrate-producing taxa, an increase of bacteria with pro-inflammatory potentials, as Ruminococcus and Streptococcus , and a decrease in abundance of Akkermansia muciniphila , which shows a potential protective role in T2D development [56]

Clinical trials have demonstrated that nausea, vomiting, diarrhoea, and abdominal discomfort are amongst the most commonly reported adverse reactions, particularly during the initial weeks of treatment or following dose escalation

Furthermore, if misused or used at excessively high doses without medical supervision, there are risks of thyroid C-cell tumors, and in men, risks of erectile dysfunction and testosterone deciency