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Glucagon also contributes to energy homeostasis by promoting satiety through vagal signaling to brainstem nuclei and by increasing resting energy expenditure through facultative thermogenesis in brown adipose tissue, skeletal muscle, and through promotion of WAT browning [22]

Class effects, which are directly related to the mechanism of action, are common to all DPP4i

Abbreviations AC, Adenylyl Cyclase

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