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This is where some people get confused
Clinicians often follow a cadence during initiation and titration, with earlier visits or check-ins in the first 4 to 12 weeks when side effects and weight change most rapidly, then wider spacing as things stabilize
it is likely to translate into better real-world adherence, and better adherence is the most important determinant of long-term therapeutic outcomes in chronic disease management
This effect is thought to be mediated by increasing natriuresis (35) and vasorelaxation in the renal vasculature (36)
