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In addition, in vitro models of primary human adipose stem cells, researchers detected intracellular fat content and quantitative expression of early and mature adipocyte markers (PPAR, FABP4, and HSL), demonstrating that glucagon can significantly reduce adipocyte differentiation, inhibit adipocyte proliferation and adipogenesis

Indirect mechanisms relate to weight loss, improved glycaemic control, and reduced visceral adiposityall of which independently contribute to lower inflammatory burden

Sitagliptin is another weapon in the arsenal of oral antihyperglycemic agents

Yes, regular exercise enhances its benefits