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The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course

Our capabilities include: High-protein nutritional formulations Muscle preservation and recovery solutions Gastrointestinal support formulations Micronutrient replenishment systems Specialized clinical nutrition products Custom product development for healthcare brands and institutions As GLP-1 therapies continue to evolve, personalized nutrition will become an essential component of patient success

The new formulation of the obesity drug places Novo a step ahead of its competitor, Eli Lilly, whose rival drug orforglipron is still being assessed by regulators

A mitochondrial switch ("SLC25A45") controls whether mitochondria burn fat or carbohydrate, and removing it (in mice) makes GLP-1 drugs stop working for fat loss entirely