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Do oral GLP-1s work as well as injectables
However, vagal afferents and vagal afferent GLP-1 receptors are presumably less important for the effects of peripheral GLP-1 on body mass
Consistent with this, GLP-1, exendin-4, and the DPP-4 inhibitor sitagliptin reduced proximal tubular sodium reabsorption in rats [660,761,769,770] and humans [663]
Even with insurance, tirzepatide copays can exceed $1,500 per month because Aetna and other insurers often classify it as a specialty tier drug
