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Here, we focus on the underlying mechanism of IR including direct defective of insulin signaling, epidemiological factors, interorgan metabolic crosstalk, metabolic mediators, genetic mutation, epigenetic dysregulation, non-coding RNAs, and gut microbiota dysbiosis
A review by Alorfi et al
Many patients notice they have more energy for daily tasks and workouts
It gained further approval on December 23, 2014, for obesity
