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Effect of liraglutide on estimates of lipolysis and lipid oxidation in obese patients with stable coronary artery disease and newly diagnosed type 2 diabetes: a randomized trial
GLP-1 mediates its physiological effects by interacting with members of the guanine nucleotide binding protein (G-protein) coupled receptor family20)

A 2023 head-to-head observational study published in JAMA Internal Medicine confirmed this real-world advantage, finding tirzepatide users lost significantly more weight than semaglutide users over comparable treatment periods

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