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Across all trials, 10,442 participants (44.2%) were female, participants mean HbA 1c at baseline was 66.6 mmol/mol (8.3%), mean body weight was 88.8 kg and mean age was 57.8 years (Table 1)

the route simply changes the speed of absorption

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Microbiota-gut-brain axis: communication pathways The MGBA acts through specific communication pathways in controlling gut functions (e.g., gut motility and secretion), activating local immune responses, modulating CNS functions (e.g., mood, and psychiatric conditions associated with stress and memory), and controlling metabolism [6]