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One notable finding from meta-analyses: cagrilintide demonstrated the lowest odds ratios for nausea, vomiting, and diarrhea when compared to other incretin-based therapies including semaglutide and tirzepatide

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Long-term cardiovascular effects Heart disease and heart failure are more common in people with overweight or obesity, and treatment options have often been limited

This multi-receptor mechanism distinguishes it from existing licensed agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist)