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In the brain, GLP-1 secreted from intestinal cells can be absorbed into the brain, and GLP-1 secreted from neurons remains in the CSF (Holscher, 2012)
In the latter half of the century, a deeper understanding of metabolism and appetite regulation led to more sophisticated approaches
As more medications arrive, the more useful question is which one suits which person, and what someone is doing alongside it to make the weight loss last
Taking multiple doses or timing your doses appropriately can help you manage these rebound effects
