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Trikafta/Kaftrio (elexacaftor/tezacaftor/ivacaftor) Disease area(s): Respiratory/rare disease Manufacturer(s): Vertex Pharmaceuticals Incorporated 2024 Sales (USD): $10.24 billion Why it sold so well: Trikafta (marketed as Kaftrio outside the US), a combination therapy of elexacaftor, tezacaftor and ivacaftor, was the primary driver of Vertex Pharmaceuticals strong commercial performance in 2024

Similarly, Mounjaro/Zepbound is fuelling Eli Lilly's ascent as the most valued drug maker in the world