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Moreover, the reduced splanchnic blood flow could affect nutrient uptake or affect digestion (107) leads to uncertainty regarding effects on memory and cognitive functions
In a phase 2 clinical trial, CagriSema reduced HbA1c by 2.2% (p = 0.075) in comparison with semaglutide 2.4 mg alone [101]
In the context of MASLD/MASH, analogous rebound phenomena would be expected: regression of achieved steatosis resolution and potential re-emergence of inflammatory activity and fibrogenic stimuli upon drug withdrawal
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