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Supplements like berberine work through different mechanisms and produce much smaller effects

L., Richardson, K
Use in Non-Diabetic Patients Semaglutide 2.4 mg (Wegovy) has shown CV benefit in SELECT trial for people with obesity without diabetes, reducing the risk of major cardiovascular events

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF
