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According to the 2023 "Report on the Nutritional and Chronic Disease Status of Chinese Residents," as of 2023, the population of overweight and obese individuals in China has exceeded 530 million, making China the country with the highest number of obese people globally

Exceeding that limit without prior authorization produces a CO-96 or CO-119 denial (maximum benefit reached)

(5.4) Vitamin B12 Deficiency: Metformin may lower vitamin B12 levels

After review of additional data, the 2023 ACC/AHA Guidelines for the Management of Patients with Chronic Coronary Disease published a strong (Class 1, LoE A) recommendation for the use of GLP-1 RA with proven cardiovascular benefits in patients with diabetes and chronic coronary disease to reduce the risk of MACE