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The present recommendations of the American and European Diabetes Associations are currently updating their actual recommendation for the treatment algorithm for T2D ( Tirzepatide may also become an important pharmacological tool for the treatment of obesity if data from the SURMOUNT-1 trial are confirmed in other clinical studies (82)

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thus, the role of GLP-1RA in humans is the same as the conclusion reached by cell and animal experimental studies

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Mice homozygous for a dominant negative Pax6 mutation (SEYNeu) have repressed Gcg expression in enteroendocrine cells in the small and large bowel and absence of immunoreactive GLP-1 and GLP-2 [109]

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2 Long-term side effects associated with GLP-1-RA use have still not been established

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