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However, common commentary is intended to highlight issues where FDA and EMA are working toward a more harmonized view (or to provide clarity for sponsors on areas where the agency may be unable to reach alignment)
Moderate alcohol is not contraindicated, but semaglutide can amplify alcohol's effects on blood sugar and on the gut
In doing so, we advocate for a paradigm that moves beyond traditional indications, embracing the full spectrum of GLP-1R agonists in areas such as primary prevention, microvascular protection, and metabolic liver disease, and metabolic disorders that include cardio-kidney-metabolic (CKM) syndromea systemic disorder characterized by interrelated metabolic, renal, and cardiovascular dysfunction and a broader cardio-renal-metabolic axis that includes central obesity, insulin resistance, dyslipidemia, hypertension, and pre-diabetic states
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