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And Eli Lilly and Companys new oral GLP-1 obesity therapy orforglipron shines in late-phase clinical trials

In WT mice and in isolated atrial cardiomyocytes, liraglutide stimulates the production and secretion of atrial natriuretic peptide (ANP), and liraglutide fails to induce natriuresis and to lower BP in ANP KO mice [640]

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Significant reductions in waistline and blood pressure were recorded, alongside improved glycemic parameters in prediabetic subjects
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