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All we can do now is watch what happens as patients hear this news and their providers and pharmacists work to get them a new prescription for the FDA-approved drug, Brunner said in the statement

Rejection Sensitive Dysphoria (RSD) is recognized by many providers but is not in the DSM

Its likely that GLP-1 RAs (or their combinations) will be part of a future MASH therapy regimen, given weight loss is the cornerstone treatment and GLP-1 causes weight loss plus some direct hepatic fat reduction

But the insights around GLP-1 receptors and the nodose ganglion may be one of the most intriguingand clinically actionablepieces of the puzzle so far