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Adipose tissue macrophage infiltration and polarization toward the pro-inflammatory M1 phenotype further amplify systemic cytokine production in the context of central obesity, creating a self-reinforcing cycle of adipose dysfunction, systemic inflammation, and metabolic deterioration

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Mounjaro and Ozempic are not the same, although they both fall under the category of GLP-1 receptor agonists used for diabetes management and weight loss