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[16] [17] Semaglutide (as Wegovy) is further indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management, including weight loss and weight maintenance, in adults with obesity (initial BMI 30 kg/m 2 ) or who are overweight (initial BMI 27 kg/m 2 ) and have at least one weight-related comorbidity such as dysglycemia (prediabetes or type 2 diabetes), hypertension, dyslipidemia, or cardiovascular disease

Through intricate biochemical routes like the WoodLjungdahl and acrylate pathways, these bacteria metabolize fiber and produce highly bioactive end-products known as Short-Chain Fatty Acids (SCFAs)

P-values less than 0.05 were considered statistically significant

Semaglutide and Oxidative Stress Regulation The improvement of inflammation and oxidative stress by semaglutide seems to be related both by modulating SIRT1/NRF2 signaling and suppressing the activated JNK/NF-B pathways [80,152]