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Since insulin resistance plays a crucial role in the pathogenesis of NAFLD and NASH, GLP-1 and its analogs have been considered a promising therapy for these conditions

Berberine alone causes diarrhea in 15 to 25% of users at 1000 to 1500mg daily and gastrointestinal discomfort in up to 35% in clinical trials

GLP-1s also reduce the rate at which the stomach digests food and empties, reducing appetite and make you feel fuller longer
