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In fact, this study shows that the levels of these molecules are significantly lower in joint fluid than in the blood/plasma and may be incidental to the function of the joints. Jeffrey Zarin, MD Also, there did not seem to be a difference between patients that had arthritis and those that did not, so conclusions about the effect of GLP-1 on arthritis should also be interpreted cautiously, Zarin added

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Clinical trials indicate that tirzepatide surpasses the weight loss achieved with some other GLP-1 receptor agonists

10.1007/s40265-020-01435-4 Drugs