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Description
2022GIPR is predominantly localized to nonadipocyte cell types within White adipose tissue
This makes peptides the obvious choice when mimicking receptor interactions
Our results indicate that exendin-4 increased CSMC cAMP levels in a dose-dependent fashion, indicating that GLP-1R mediates its effects in CSMCs through activation of adenylyl cyclase, leading in turn to cAMP-dependent activation of various second messenger pathways (Figure 6C)
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