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10.1152/ajpendo.1996.271.3.E458 43

There are also more serious side effects that can occur, though they are less common
This introduces variability in pharmacodynamics, as GLP-1RA penetration into specific brain regions may differ based on sex, compound properties, and age (Borchers and Skibicka, 2025)

Without adequate dietary calcium plus supplementation, the deficit compounds week after week
