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While they are very effective in treating diabetes and assisting with weight loss, there is a great deal of concern regarding potential adverse effects, including stomach paralysis

In June 2023, an international, multi-society guided Delphi process established the definition of metabolic dysfunction-associated steatotic liver disease (MASLD), which is defined as the presence of high triglyceride (TG) storage inside the hepatocytes in the presence of at least one cardiometabolic risk factor, trying to unveil the nuances of a heterogenous and complex disorder [6, 7]

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Uniquely, these two agents from the same company may work as a complementary pair: the ATTAIN-MAINTAIN trial demonstrated that patients can achieve maximum weight loss with injectable tirzepatide and then switch to oral orforglipron for maintenance