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Description
Given the intractable pediatric obesity epidemic and associated rise in type 2 diabetes in youth, made worse by the COVID-19 pandemic related shutdowns and disruptions in opportunities for exercise and play in youth, this new class of medications will certainly benefit children with morbid obesity and type 2 diabetes
Translation: potentially enhanced appetite suppression and metabolic benefits
October 5, 2011
In 2020 the first small-molecule structure (Zhao et al) revealed a druggable transmembrane sub-pocket distinct from the peptide-binding interface
