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BBR decreases the absorption of intestinal cholesterol by interfering with micellization and encourages cholesterol excretion through enterocytes [46]

SR18 exhibited an average hydrodynamic diameter of 4.001 nm with a polydispersity index (PDI) of 0.2289, indicating a relatively uniform and predominantly monomeric population in 1 X PBS, compared to 10 M BSA (hydrodynamic diameter 7.631 nm and PDI 0.1645) as shown in Supplementary Figure S5

These agents demonstrated superior glycemic efficacy compared with many earlier therapies and offered clinically meaningful weight reduction, establishing a new standard of care for patients with type 2 diabetes and obesity