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The trabecular density of GLP-1R and GIPR double KO mice was higher than that of the wild-type control group, but the cortical thickness, cortical area, and external diameter of bone decreased (Mieczkowska et al., 2015)
But newer research revealed that GIP receptor activation in the brain actually reduces appetite, and when combined with GLP-1 receptor activation, the metabolic benefits multiply
[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Sun, X
This rebound occurs because GLP-1 medications work by resetting appetite regulation in the brainstopping the medication doesn't maintain those changes
