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Description
As a triple agonist targeting GLP-1, GIP, and GCG receptors, retatrutride represents an advanced approach to managing type 2 diabetes and obesity
Interestingly, glucose-dependent insulinotropic polypeptide levels were not sex divergent in the same study, suggesting that among incretins GLP-1 may be more prone to sex differences, at least in the setting tested
The near-zero hypoglycemia rate (0.6% of participants) directly confirmed the glucose-dependent nature of the insulin secretory mechanism in a clinical population
Whilst this has not been conclusively demonstrated in humans, caution is advised in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2)
